cell cycle arrest — TargetMol Chemicals

Cat No.	Product Name	Synonyms	Targets
T11960	MBM-55		GSK-3 , MAPK , DYRK , Akt , Chk , Bcr-Abl , CDK , S6 Kinase , Aurora Kinase
	MBM-55 is an effective inhibitor of NIMA related kinase 2 (NEK2) with an IC50 of 1 nM. MBM-55 effectively inhibits the proliferation of cancer cells by inducing cell cycle arrest and apoptosis.
T14066	9-ING-41		Apoptosis , GSK-3 , Autophagy
	9-ING-41 is a glycogen synthase kinase-3 inhibitor.		Apoptosis , GSK-3 , Autophagy
T23133	Pentamidine		Phosphatase , Antibacterial , Antibiotic , Parasite , Antifungal
	Pentamidine is an antifungal and antiprotozoal agent, interacting directly with the pathogen genome by binding to AT-rich regions of duplex DNA and the minor groove of DNA, thereby interfering with DNA replication.
T6207	SC144		Apoptosis , Interleukin
	SC144 is an orally active small-molecule gp130 inhibitor.		Apoptosis , Interleukin
T22461	YKL-5-124		CDK
	YKL-5-124, a potent, selective and covalent CDK7 inhibitor with an IC50 of 9.7 nM, 1300 nM and 3020 nM for CDK7/Mat1/CycH, CDK2 and CDK9 respectively, displays biochemical and cellular selectivity for CDK7 over CDK12/13...		CDK
T15012	Crolibulin	EPC2407	Microtubule Associated
	Crolibulin (EPC2407) is an inhibitor of small molecule tubulin polymerization.		Microtubule Associated
TN1019	Beta-mangostin	β-Mangostin	Apoptosis , Antibacterial , Parasite
	Beta-mangostin (β-Mangostin) is a xanthone compound with antibacterial and antimalarial activities. Beta-mangostin present in Cratoxylum arborescens and exhibits antimycobacterial activity against Mycobacterium tuberculo...		Apoptosis , Antibacterial , Parasite
T36816	S-trityl-L-Cysteine	STLC	Kinesin
	S-trityl-L-Cysteine is a non-natural amino acid and an inhibitor of Eg5, also known as KSP and Kif11, a mitotic kinesin necessary for mitotic spindle formation. S-trityl-L-Cysteine inhibits the ATPase activity of Eg5 in ...		Kinesin
T6303	CCT128930		Akt , PKA , S6 Kinase , Autophagy
	CCT128930 is a potent, ATP-competitive and selective inhibitor of Akt2 with IC50 of 6 nM, 28-fold greater selectivity for Akt2 than the closely related PKA kinase.		Akt , PKA , S6 Kinase , Autophagy
T10460	Batabulin	T138067	Apoptosis , Microtubule Associated
	Batabulin (T138067) is an antitumor compound, which binds covalently and selectively to a subset of the β-tubulin isotypes, thereby disrupting microtubule polymerization. Batabulin affects cell morphology and leads to ce...		Apoptosis , Microtubule Associated
T2764	(S)-10-Hydroxycamptothecin	10-Hydroxycamptothecin,10-HCPT	Apoptosis , Topoisomerase
	(S)-10-Hydroxycamptothecin (10-HCPT) is a DNA topoisomerase I inhibitor, utilized as a clinical therapy agent against hepatoma.		Apoptosis , Topoisomerase
T1654	Pentamidine isethionate	Pentamidine isethionate salt,Pentamidine diisethionate	Phosphatase , Antibacterial , Antibiotic , Parasite , Antifungal
	Pentamidine isethionate (Pentamidine diisethionate) is a synthetic amidine derivative, Pentamidine Isethionate is an antiprotozoal and antifungal agent.
T2641	KRCA-0008	KRCA 0008,KRCA0008	ACK , ALK
	KRCA-0008 is an effective and specific ALK/Ack1 inhibitor (IC50: 12/4 nM); displays drug-like properties without hERG liability.		ACK , ALK
T4215	TCS-PIM-1-4a	SMI-4a	Apoptosis , Pim
	TCS-PIM-1-4a (SMI-4a), a Pim inhibitor, blocks mTORC1 activity through activation of AMPK and kills a wide range of both myeloid and lymphoid cell lines (IC50=0.8-40 μM).		Apoptosis , Pim
T4134	OTS514 hydrochloride	OTS-514 hydrochloride,OTS514 hydrochloride(1338540-63-8(free base))	Apoptosis , TOPK
	OTS514 hydrochloride is a highly effective TOPK(T-LAK cell-originated protein kinase) inhibitor (IC50: 2.6 nM).		Apoptosis , TOPK
T23132	Pentamidine dihydrochloride	MP-601205 dihydrochloride	Phosphatase , Antibacterial , Antibiotic , Parasite , Antifungal
	Pentamidine dihydrochloride (MP-601205 dihydrochloride) is an aromatic diamidine agent with activity against a number of microorganisms including protozoa (Trypanosoma brucei, Leishmania spp., and Babesia spp.) and fungi...
T6303L	CCT128930 hydrochloride	CCT128930 hydrochloride(885499-61-6 Free base)	Apoptosis , Akt , PKA , mTOR , Autophagy
	CCT128930 hydrochloride (CCT128930 hydrochloride) is a potent and selective inhibitor of AKT with IC50 of 6 nM. CCT128930 hydrochloride induces cell cycle arrest, DNA damage, and autophagy. CCT128930 hydrochloride has 28...		Apoptosis , Akt , PKA , mTOR , Autophagy
T2241	Alisertib	MLN 8237	Apoptosis , Aurora Kinase , Autophagy
	Alisertib (MLN 8237) is a specific Aurora A inhibitor (IC50: 1.2 nM). The selectivity of Alisertib(MLN 8237) is >200-fold higher for Aurora A than Aurora B.		Apoptosis , Aurora Kinase , Autophagy
T2170	SKF-96365 hydrochloride	SKF96365	Apoptosis , Potassium Channel , Calcium Channel , TRP/TRPV Channel , Autophagy
	SKF-96365 hydrochloride (SKF96365) , a SOCE inhibitor, exhibits potent anti-neoplastic activity by inducing cell-cycle arrest and apoptosis in colorectal Y cells. SKF-96365 hydrochloride can induce cytoprotective autopha...
T4134L	OTS514	OTS514 HCl,OTS514 Hydrochloride,OTS-514,OTS 514	Apoptosis , TOPK
	OTS514 (OTS514 Hydrochloride) is a potent TOPK inhibitor. OTS514 exhibits a growth-suppressive effect on small cell lung cancer. OTS514 effectively suppressed the growth of SCLC cell lines (IC50: 0.4 ~ 42.6 nM). Treatmen...		Apoptosis , TOPK